Diseases are manifested through changes in metabolism. It is therefore highly important and relevant to elucidate mechanistic explanation of the disease to gain further insights. Any dysfunction in the secretion of insulin and/or in its use is critical in the development of type 2 diabetes. Mycobacterium tuberculosis (Mtb) inhibits Phosphatidylinositol 3-phosphate (PI3P) formation on phagosomal membrane and disrupts the process of phagosome maturation, the known host’s innate defense mechanism, to spread in the host body. Cancer is caused due to various disorders in the complex intra-and-inter cellular networks that link tissues and organs. This project will emphasize understanding of complex biological processes and open up new treatment avenues for three diseases: Diabetic, Tuberculosis and Cancer. The objectives are: (i) to study the dynamic interaction of glucose induced insulin secretion mechanism through glucose metabolism and ATP-dependent calcium influx, (ii) to investigate whether modulation of PI3P oscillations through cytosolic calcium is a potential therapeutic intervention strategy for Mycobacterium tuberculosis (Mtb), (iii) to find the predictive value of cancer cell-specific genome-scale metabolic models in ranking cancer drugs.
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